Founded in 2008, Karyopharm Therapeutics is a clinical-stage pharmaceutical company focused on discovery and development of novel drugs for the treatment of cancer, inflammation and other diseases related to cell proliferation.
Our lead products are first in class, oral Selective Inhibitors of Nuclear Export (SINE), which irreversibly block nuclear-cytoplasmic transport mediated by Exportin-1 (XPO1, also called CRM1).
We believe that our SINE compounds can provide novel, oral, well-tolerated therapies for various cancers. Furthermore, evidence suggests that SINE will also show activity in inflammatory, dermatologic and other proliferative diseases as well as infectious diseases.
In addition, Karyopharm has a growing pipeline addressing novel oncology targets which complement our XPO1 SINE program.