Resources Year All 2019 2018 2017 2016 2015 2014 2013 2012 2010 Go Search Presentation Safety and Anti-tumor Activity of Selinexor (KPT-330), a First-in-Class, Oral XPO1 Selective Inhibitor of Nuclear Export (SINE) – A Phase I Study Expanded with Colon Cancer Cohort PDF (1.49 MB) Read MorePaper XPO1 (CRM1) inhibition represses STAT3 activation to drive a surviving-dependent oncogenic switch in triple negative breast cancer. External Link Read MorePresentation Preliminary Evidence Of Anti Tumor Activity Of Selinexor (KPT-330) In a Phase I Trial Ofa First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Relapsed / Refractory Non Hodgkin’s Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL) PDF (2.17 MB) Read MorePresentation Phase I Trial of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Advanced Acute Myelogenous Leukemia (AML) PDF (1.24 MB) Read MorePresentation Anti Tumor Activity Of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist In Patients (pts) With Relapsed / Refractory Multiple Myeloma (MM) Or Waldenstrom’s Macroglobulinemia (WM) PDF (3.12 MB) Read MorePaper Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias External Link Read MorePaper Genome wide studies in Multiple Myeloma identify XPO1/CRM-1 as a critical target validated using the selective nuclear export inhibitor KPT-276. External Link Read MorePresentation A first-in-class, first-in-human Phase I trial of KPT-330, a Selective Inhibitor of Nuclear Export (SINE) in patients (pts) with advanced solid tumors PDF (2.94 MB) Read MorePaper CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF mutant melanoma External Link Read MorePaper CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications External Link Read More Previous 1 … 18 19 20 21 22 Next